The thiazolidinedione ring is an important structural moiety found in numerous pharmaceutically active compounds for diabetes treatment. This is mainly due to the ease preparation and the important versatile pharmacological activity of thiazolidinedione. When thiazolidinedione were discovered, they were mostly useful as an anti-diabetic but in recent times, they are known to exhibit anticancer activity in combination with hypoglycaemic agents. The activation of PPAR- γ receptor is the basic mechanism of these categories of drugs. The present study involves synthesis of substituted Thiazolidinedione derivatives as an anti-diabetic activity. The structure activity Relationship of 2-(4-((3-aryl-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy) -N-arylacetamide and pharmacophore pattern of target molecule suggest that it gives antidiabetic and anti-cancer activity. Substituted thiazolidinedione synthesized by knoevenagel condensation reaction between 4-hydroxy benzaldehyde and Thiazolidinedione. The synthesis of compounds was confirmed by TLC, IR, NMR and Mass spectroscopy. The synthesized compounds were screened for anti-diabetic activity. The compounds with thiazolidinedione were found active and show optimal activity. The Compound 2-(4-((3-aryl-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-arylacetamide(1) was found to be most active among the series.
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